Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis.

@article{Tang1998CleavageOD,
  title={Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis.},
  author={Damu Tang and Vincent J. Kidd},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 44},
  pages={28549-52}
}
Apoptosis involves the proteolysis of specific cellular proteins by a group of cysteine proteases known as caspases. Many of these cellular targets are either functionally inactivated (e.g. poly(ADP-ribose) polymerase) or activated (e.g. other caspases, gelsolin) by such processing, thereby facilitating the cell death process. Caspase 3 is involved in the processing of many of these proteins. Recently, however, it was reported that caspase 3 is dispensable for the cleavage of a large number of… CONTINUE READING
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Cleavage Requires Caspase 3 28552 by gest on Sptem er 7, 2017 hp://w w w .jb.org/ D ow nladed from

  • J. C. Deak, J. V. Cross, +4 authors D. J. Templeton
  • J. Biol. Chem
  • 1998

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