Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis*

@article{Tang1998CleavageOD,
  title={Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis*},
  author={D. Tang and V. Kidd},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={28549 - 28552}
}
  • D. Tang, V. Kidd
  • Published 1998
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Apoptosis involves the proteolysis of specific cellular proteins by a group of cysteine proteases known as caspases. Many of these cellular targets are either functionally inactivated (e.g. poly(ADP-ribose) polymerase) or activated (e.g. other caspases, gelsolin) by such processing, thereby facilitating the cell death process. Caspase 3 is involved in the processing of many of these proteins. Recently, however, it was reported that caspase 3 is dispensable for the cleavage of a large number of… CONTINUE READING
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