Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide.

@article{Hirako1998CleavageOB,
  title={Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide.},
  author={Yoshiako Hirako and Jiro Usukura and Jun Uematsu and Tadafumi Hashimoto and Yasuo Kitajima and Katsushi Owaribe},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 16},
  pages={
          9711-7
        }
}
The hemidesmosome (HD) is a cell-to-substrate adhesion apparatus found in stratified and complex epithelia. One of the putative cell-matrix adhesion molecules present in the HD is the 180-kDa bullous pemphigoid antigen (BP180), also termed type XVII collagen. In our previous study, using a monoclonal antibody (mAb) 1337, we have detected a 120-kDa collagenase-sensitive polypeptide in the HD fraction (Uematsu, J. and Owaribe, K. (1993) Cell Struct. Funct. 18, 588 (abstr.)). The present study was… CONTINUE READING
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