Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design.

  title={Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design.},
  author={Shailendra Sharma and Natalia de Val and Shridhar Bale and Javier Guenaga and Karen Tran and Yu Feng and Viktoriya Dubrovskaya and Andrew B. Ward and Richard T. Wyatt},
  journal={Cell reports},
  volume={11 4},
Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein (Env) trimers in the pre-fusion state (SOSIP) display molecular homogeneity and structural integrity at relatively high levels of resolution. However, the SOSIPs necessitate full Env precursor cleavage, which requires endogenous furin… CONTINUE READING
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