Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis.

@article{Rokudai2000CleavageAI,
  title={Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis.},
  author={Susumu Rokudai and Naoya Fujita and Yasuaki Hashimoto and Takashi Tsuruo},
  journal={Journal of cellular physiology},
  year={2000},
  volume={182 2},
  pages={290-6}
}
The oncogene Akt/PKB/RAC-PK is a serine/threonine kinase that mediates survival signals and has protective effects against apoptosis induced by a variety of stimuli. The kinase activity of Akt has been demonstrated to be critical in transmitting survival signals. We found that Akt protein was down-regulated during apoptosis. The down-regulation was blocked by a caspase inhibitor, indicating that Akt was cleaved by caspases during apoptosis. The Akt protein incubation with active caspases in… CONTINUE READING