Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities.


Cleavage activation of the hemagglutinin (HA) precursor is an essential step in the influenza virus replication cycle that is driven by host cell proteases. HA cleavage activation is required for virus-endosome membrane fusion and the subsequent release of the influenza virus genome into the cytoplasm. Previous studies have determined that HA cleavage is… (More)
DOI: 10.1128/JVI.00306-12

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