Cleavage, but not read-through, stimulation activity is responsible for three biologic functions of transcription elongation factor S-II.

@article{Ubukata2003CleavageBN,
  title={Cleavage, but not read-through, stimulation activity is responsible for three biologic functions of transcription elongation factor S-II.},
  author={Toshiharu Ubukata and Tomoko K. Shimizu and Nobuaki Adachi and Kazuhisa Sekimizu and Toshiyuki Nakanishi},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 10},
  pages={8580-5}
}
Transcription elongation factor S-II stimulates cleavage of nascent transcripts generated by RNA polymerase II stalled at transcription arrest sites. In vitro experiments have shown that this action promotes RNA polymerase II to read through these transcription arrest sites. This S-II-mediated cleavage is thought to be necessary, but not sufficient, to promote read-through in the in vitro systems. Therefore, Saccharomyces cerevisiae strains expressing S-II mutant proteins with different in… CONTINUE READING