Cleavable Reagent Systems

@inproceedings{Hermanson1996CleavableRS,
  title={Cleavable Reagent Systems},
  author={Greg T. Hermanson},
  year={1996}
}
Cross-linking and modification reagents may possess functions other than their reactivity toward certain chemical groups. The cross-bridge of a molecule can be designed to contain constituents that allow cleavage of the reagent after use. The coupling reaction itself provides linkages susceptible to subsequent cleavage. Cleavability allows the conjugation reaction to be verified through identification of the cross-linked molecules after the conjugation and purification of the complex. Precise… CONTINUE READING

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