Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion.

@article{HochreiterHufford2013ClearingTD,
  title={Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion.},
  author={Amelia E. Hochreiter-Hufford and Kodi Ravichandran},
  journal={Cold Spring Harbor perspectives in biology},
  year={2013},
  volume={5 1},
  pages={a008748}
}
Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably, even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. Recently, significant progress has been made in understanding the steps involved in prompt cell clearance in vivo. These include the sensing of corpses via "find me" signals, the… CONTINUE READING

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