Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity.


The importance of mass and concentration, rather than percentage, in determining the safety of risk of metabolites has been the subject of recent scholarship. These studies have not examined the dimension of time as represented by the duration of exposure to the chemical. Reviewing a wide range of clinical information duration of exposure is not a pivotal… (More)
DOI: 10.1016/j.cbi.2008.09.022


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