Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

@article{Mailly2015ClearanceOP,
  title={Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody},
  author={Laurent Mailly and Fei Xiao and Joachim Lupberger and Garrick K. Wilson and P Aubert and François H. T. Duong and Diego Calabrese and C{\'e}line Leboeuf and Isabel Fofana and Christine Thumann and Simonetta Bandiera and Marc L{\"u}tgehetmann and Tassilo Volz and Christopher Davis and Helen J. Harris and Christopher J. Mee and Erika Girardi and B{\'e}atrice Chane-Woon-Ming and Maria Ericsson and Nicola Fletcher and Ralf Bartenschlager and Patrick Pessaux and Koen Vercauteren and Philip Meuleman and Pascal Villa and Lars Kaderali and S{\'e}bastien Pfeffer and Markus H Heim and Michel Neunlist and Mirjam B. Zeisel and Maura Dandri and Jane A McKeating and Eric Robinet and Thomas F Baumert},
  journal={Nature Biotechnology},
  year={2015},
  volume={33},
  pages={549-554}
}
Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer. Cell entry of HCV and other pathogens is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver–chimeric mouse model, we show that a monoclonal antibody specific for the TJ protein claudin… CONTINUE READING