Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.

@article{Herrmann2012ClearanceOF,
  title={Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.},
  author={Marietta Herrmann and Cora Sch{\"a}fer and Alexander Heiss and Steffen Gr{\"a}ber and Anne Kinkeldey and Andrea Buescher and Martin M. N. Schmitt and J{\"o}rg Bornemann and Falk Nimmerjahn and Martin Herrmann and Laura Helming and Siamon Gordon and Willi Jahnen-Dechent},
  journal={Circulation research},
  year={2012},
  volume={111 5},
  pages={575-84}
}
RATIONALE Fetuin-A is a liver-derived plasma protein involved in the regulation of calcified matrix metabolism. Biochemical studies showed that fetuin-A is essential for the formation of protein-mineral complexes, called calciprotein particles (CPPs). CPPs must be cleared from circulation to prevent local deposition and pathological calcification. OBJECTIVE We studied CPP clearance in mice and in cell culture to identify the tissues, cells, and receptors involved in the clearance. METHODS… CONTINUE READING
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Fetuin-A protects against atherosclerotic calcification in CKD.

Journal of the American Society of Nephrology : JASN • 2009

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