Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.

@article{Hama2001ClearanceOE,
  title={Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.},
  author={Emi Hama and Keiro Shirotani and Hajime Masumoto and Yoko Sekine-Aizawa and Hiroyuki Aizawa and Takaomi C Saido},
  journal={Journal of biochemistry},
  year={2001},
  volume={130 6},
  pages={721-6}
}
Amyloid beta peptide (Abeta), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite constantly anabolized and catabolized in the brain. We previously demonstrated that neprilysin is the major Abeta-degrading enzyme in vivo. To investigate whether or not manipulation of neprilysin activity in the brain would be an effective strategy for regulating Abeta levels, we expressed neprilysin in primary cortical neurons using a Sindbis viral vector and examined the effect on… CONTINUE READING

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