Clearance of dying ARPE-19 cells by professional and nonprofessional phagocytes in vitro- implications for age-related macular degeneration (AMD).

@article{Petrovski2011ClearanceOD,
  title={Clearance of dying ARPE-19 cells by professional and nonprofessional phagocytes in vitro- implications for age-related macular degeneration (AMD).},
  author={Goran Petrovski and Erika Ber{\'e}nyi and Morten C Moe and Attila Vajas and L{\'a}szl{\'o} F{\'e}s{\"u}s and Andr{\'a}s Berta and Andrea Facsk{\'o}},
  journal={Acta ophthalmologica},
  year={2011},
  volume={89 1},
  pages={e30-4}
}
PURPOSE Failure of retinal pigment epithelial (RPE) cells and macrophages to engulf different dying cells in the retina may result in accumulation of debris and development of age-related macular degeneration (AMD). The dynamics and influence of different treatments on this clearance process can be studied in vitro using human ARPE-19 cells and macrophages as phagocytes modelling dry and wet type of AMD, respectively. METHODS Death through extracellular matrix detachment using polyHEMA-coated… CONTINUE READING

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