Clearance of circulating endothelin-1 by ETB receptors in rats.

  title={Clearance of circulating endothelin-1 by ETB receptors in rats.},
  author={Takahiro Fukuroda and Toru Fujikawa and Sei Ozaki and Kumi Ishikawa and Mihiro Yano and Masaru Nishikibe},
  journal={Biochemical and biophysical research communications},
  volume={199 3},
Exogenous endothelin (ET) is rapidly cleared from the circulation. We investigated which ET receptor subtypes (ETA and ETB) participate in ET-1 clearance. Following an intravenous (i.v.) bolus dose of [125I]ET-1 in anesthetized rats, radioactivity was rapidly cleared from the circulation and trapped by the lungs, kidneys and liver. Tissue distribution of the radioactivity was significantly inhibited in the lungs and kidneys, but not in the liver by infusion of the ETB antagonist BQ-788 (0.1 mg… CONTINUE READING

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