Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo.

@article{Yang1995ClearanceOA,
  title={Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo.},
  author={Yun-Sheng Yang and Janice M. Wilson},
  journal={Journal of immunology},
  year={1995},
  volume={155 5},
  pages={
          2564-70
        }
}
E1-deleted recombinant adenoviruses have been developed for liver-directed gene therapy because efficient gene transfer to hepatocytes can be achieved in vivo. However, these viruses also express viral proteins in hepatocytes, leading to the development of destructive immune responses. Our previous studies indicated that MHC class I-restricted C D8+CTLs are major effectors in eliminating virus-infected cells, and CD4+ cells are also necessary in developing a fully competent CTL response by… CONTINUE READING

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