Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement.

@article{Xu2008ClearanceOA,
  title={Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement.},
  author={Zhili Xu and Jie Tian and Jeffrey S Smith and Andrew P Byrnes},
  journal={Journal of virology},
  year={2008},
  volume={82 23},
  pages={11705-13}
}
Kupffer cells (KCs) rapidly remove intravenously injected adenovirus (Ad) vectors from the circulation. A better understanding of the mechanisms involved could suggest strategies to improve Ad gene delivery by suppressing or evading KC uptake. We recently showed that clearance of Ad type 5 vectors by KCs does not involve the interaction of Ad with the well-established Ad receptors, namely, integrins or the coxsackievirus and Ad receptor (J. S. Smith, Z. Xu, J. Tian, S. C. Stevenson, and A. P… CONTINUE READING
69 Citations
70 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 70 references

Similar Papers

Loading similar papers…