Clearance of IgE from serum of normal and hybridoma-bearing mice.

@article{Haba1985ClearanceOI,
  title={Clearance of IgE from serum of normal and hybridoma-bearing mice.},
  author={S Haba and Zoltan Ovary and Alfred Nisonoff},
  journal={Journal of immunology},
  year={1985},
  volume={134 5},
  pages={
          3291-7
        }
}
The half-life of IgE in the mouse was investigated by using radiolabeled and unlabeled monoclonal antibodies of the IgE class. Quantitative serologic assays were used for the unlabeled antibodies. IgE was cleared rapidly upon i.v. inoculation; after 48 hr, less than 0.2% of the initial concentration remained in the serum. The IgE was cleared initially with a half-life of 1 to 2 hr, attaining a relatively constant value of 5 to 8 hr. The corresponding values for IgG1, determined as a control… CONTINUE READING

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