Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis.

@article{Brown2010ClearanceOC,
  title={Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis.},
  author={Julia A. Brown and Kristen E. Stevenson and Haesook T Kim and Corey S Cutler and Karen Kuhn Ballen and Sean M McDonough and Carol G. Reynolds and Mar{\'i}a Isabel Herrera and Deborah Liney and Vincent Trien-Vinh Ho and Grace S Kao and Philippe A Armand and John Koreth and Edwin P Alyea and Steve L McAfee and Eyal C. Attar and Bimalangshu R. Dey and Thomas R. Spitzer and Robert J. Soiffer and Jerome Ritz and Joseph H Antin and Vassiliki A Boussiotis},
  journal={Blood},
  year={2010},
  volume={115 20},
  pages={4111-9}
}
Umbilical cord blood grafts are increasingly used as sources of hematopoietic stem cells in adults. Data regarding the outcome of this approach in adults are consistent with delayed and insufficient immune reconstitution resulting in high infection-related morbidity and mortality. Using cytomegalovirus (CMV)-specific immunity as a paradigm, we evaluated the status, mechanism, and clinical implications of immune reconstitution in adults with hematologic malignancies undergoing unrelated double… CONTINUE READING
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