Clearance: The Last and Often Forgotten Stage of Apoptosis

  title={Clearance: The Last and Often Forgotten Stage of Apoptosis},
  author={V. Fadok},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  • V. Fadok
  • Published 2004
  • Medicine, Biology
  • Journal of Mammary Gland Biology and Neoplasia
  • Engulfment by a phagocyte is the final commonevent in the life of most apoptotic cells. Phagocytosisof apoptotic bodies prior to their lysis prevents therelease of potentially toxic or immunogenicintracellular contents and activates an anti-inflammatoryresponse, at least in macrophages. We are beginning tounderstand the mechanisms by which macrophages and otherphagocytes recognize apoptotic cells in vitro, but we are a long way from determining theirrelative importance in vivo. The involuting… CONTINUE READING
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