Clearance: The Last and Often Forgotten Stage of Apoptosis

@article{Fadok2004ClearanceTL,
  title={Clearance: The Last and Often Forgotten Stage of Apoptosis},
  author={Valerie Fadok},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={4},
  pages={203-211}
}
  • V. Fadok
  • Published 1 April 1999
  • Biology
  • Journal of Mammary Gland Biology and Neoplasia
Engulfment by a phagocyte is the final commonevent in the life of most apoptotic cells. Phagocytosisof apoptotic bodies prior to their lysis prevents therelease of potentially toxic or immunogenicintracellular contents and activates an anti-inflammatoryresponse, at least in macrophages. We are beginning tounderstand the mechanisms by which macrophages and otherphagocytes recognize apoptotic cells in vitro, but we are a long way from determining theirrelative importance in vivo. The involuting… 

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  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2002
The known molecular aspects of phagocytosis of apoptotic corpses in mammals, Caenorhabditis elegans and Drosophila melanogaster are reviewed from the point of view of the phagocyte and the apoptotic corpse.

PHAGOCYTOSIS OF APOPTOTIC CELLS IN MAMMALS, CAENORHABDITIS ELEGANS AND DROSOPHILA MELANOGASTER: MOLECULAR MECHANISMS AND PHYSIOLOGICAL CONSEQUENCES

The known molecular aspects of phagocytosis of apoptotic corpses in mammals, Caenorhabditis elegans and Drosophila melanogaster are reviewed from the point of view of the phagocyte and the apoptotic corpse.

Massive apoptosis of colonocytes induced by butyrate deprivation overloads resident macrophages and promotes the recruitment of circulating monocytes

Butyrate deprivation in vivo led to untimely death of colonocytes and triggered changes in the lamina propria indicative of an inflammatory response.

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

PPAR-δ has a pivotal role in orchestrating the timely disposal of apoptotic cells by macrophages, ensuring that tolerance to self is maintained.

Expulsion of Live Pathogenic Yeast by Macrophages

...

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