Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression.

@article{Joseph2016ClearCR,
  title={Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression.},
  author={Richard W. Joseph and Payal Kapur and Daniel J. Serie and Mansi A. Parasramka and Thai H. Ho and John C. Cheville and Eugene P. Frenkel and Alexander Scott Parker and James Brugarolas},
  journal={The Journal of urology},
  year={2016},
  volume={195 1},
  pages={
          180-7
        }
}
PURPOSE In clear cell renal cell carcinoma BAP1 and PBRM1 are 2 of the most commonly mutated genes (10% to 15% and 40% to 50%, respectively). We sought to determine the prognostic significance of PBRM1 and BAP1 expression in clear cell renal cell carcinoma. MATERIALS AND METHODS We used immunohistochemistry to assess PBRM1 protein expression in 1,479 primary clear cell renal cell carcinoma tumors that were previously stained for BAP1. A centralized pathologist reviewed all cases and… CONTINUE READING
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