Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance.

@article{Zhao2015CleaningUA,
  title={Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance.},
  author={Xiurong Zhao and Guanghua Sun and Shun-Ming Ting and Shen Song and Jie Zhang and Nancy J. Edwards and Jaroslaw Aronowski},
  journal={Journal of neurochemistry},
  year={2015},
  volume={133 1},
  pages={
          144-52
        }
}
As a consequence of intracerebral hemorrhage (ICH), blood components enter brain parenchyma causing progressive damage to the surrounding brain. Unless hematoma is cleared, the reservoirs of blood continue to inflict injury to neurovascular structures and blunt the brain repair processes. Microglia/macrophages (MMΦ) represent the primary phagocytic system that mediates the cleanup of hematoma. Thus, the efficacy of phagocytic function by MMΦ is an essential step in limiting ICH-mediated damage… CONTINUE READING

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