Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice

@article{Kim2015ClavulanicAE,
  title={Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice},
  author={Jae Kyeum Kim and J. Shin John and Dianne Langford and Ellen Ann Walker and Sara Ward and Scott Manning Rawls},
  journal={Amino Acids},
  year={2015},
  volume={48},
  pages={689-696}
}
The β-lactam antibiotic ceftriaxone (CTX) reduces cocaine reinforcement and relapse in preclinical assays through a mechanism involving activation of glutamate transporter subtype 1 (GLT-1). However, its poor brain penetrability and intravenous administration route may limit its therapeutic utility for indications related to CNS diseases. An alternative is clavulanic acid (CA), a structural analog of CTX that retains the β-lactam core required for GLT-1 activity but displays enhanced brain… CONTINUE READING

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