Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function.

@article{Amasheh2011ClaudinsOI,
  title={Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function.},
  author={Salah Amasheh and Michael Fromm and Dorothee G{\"u}nzel},
  journal={Acta physiologica},
  year={2011},
  volume={201 1},
  pages={133-40}
}
A prerequisite of epithelial transport is a paracellular barrier function, which seals the tissue against an uncontrolled leak flux. Moreover, selective paracellular permeability has been shown to be crucial for physiological epithelial transport function. Claudins are tetraspan tight junction proteins which play a major role in paracellular ion permeability across epithelia. The multigene family consists of 24 members and several splice variants which show distinct tissue-specific expression… CONTINUE READING

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