Claudins and renal salt transport

  title={Claudins and renal salt transport},
  author={Shigeaki Muto and Mikio Furuse and Eiji Kusano},
  journal={Clinical and Experimental Nephrology},
Tight junctions (TJs) are the most apical component of junctional complexes and regulate the movement of electrolytes and solutes by the paracellular pathway across epithelia. The defining ultrastructural features of TJs are strands of transmembrane protein particles that adhere to similar strands on adjacent cells. These strands are mainly composed of linearly polymerized integral membrane proteins called claudins. Claudins comprise a multigene family consisting of more than 20 members in… CONTINUE READING
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