Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associated with metastatic behavior.

@article{Takala2007Claudins13,
  title={Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associated with metastatic behavior.},
  author={Heikki Takala and Juha Saarnio and Heikki Wiik and Ylermi M Soini},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2007},
  volume={115 7},
  pages={838-47}
}
The aim of the study was to elucidate the significance of claudins in surgically treated esophageal carcinoma. The expression of claudins 1, 3, 4, 5 and 7 was studied by immunohistochemistry. Tumor proliferation was assessed with Ki67 immunostaining and apoptosis by the TUNEL method and immunostaining of fragmented caspase 3. Adenocarcinomas showed significantly more cases with moderate or strong claudin 3 (p<0.001) and claudin 5 positivity (p=0.031) compared to squamous cell carcinomas. Loss… CONTINUE READING

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