Claudins: multifunctional players in epithelial tight junctions and their role in cancer

@article{Oliveira2006ClaudinsMP,
  title={Claudins: multifunctional players in epithelial tight junctions and their role in cancer},
  author={Silvia Priscila de Oliveira and Jose Andr{\'e}s Morgado-D{\'i}az},
  journal={Cellular and Molecular Life Sciences},
  year={2006},
  volume={64},
  pages={17-28}
}
The molecular architecture of tight junctions has been a subject of extensive studies that have shown tight junctions to be composed of many peripheral and integral membrane proteins. Claudins have been considered the main tight junction-forming proteins; however, the role they play in a series of pathophysiological events, including human carcinoma development, is only now beginning to be understood. Increasing evidence from in vitro and in vivo studies have identified the influence of… CONTINUE READING
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