Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.

@article{Colegio2003ClaudinED,
  title={Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.},
  author={Oscar R. Colegio and Christina M Van Itallie and Christoph Rahner and James Melvin Anderson},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={284 6},
  pages={C1346-54}
}
Tight junctions (TJs) regulate paracellular permeability across epithelia and vary widely in their transepithelial electrical resistance (TER) and charge selectivity. The claudin family of transmembrane proteins influences these properties. We previously reported that claudin-4 increased TER approximately 300% when expressed in low-resistance Madin-Darby canine kidney (MDCK) II cells and decreased the paracellular permeability for Na(+) more than Cl(-) (Van Itallie C, Rahner C, and Anderson JM… CONTINUE READING