Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis

Abstract

In normal colon, claudin-7 is one of the highly expressed claudin proteins and its knockdown in mice results in altered epithelial cell homeostasis and neonatal death. Notably, dysregulation of the epithelial homeostasis potentiates oncogenic transformation and growth. However, the role of claudin-7 in the regulation of colon tumorigenesis remains poorly… (More)
DOI: 10.1038/onc.2014.385

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