Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells.

@article{Amasheh2002Claudin2EI,
  title={Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells.},
  author={Salah Amasheh and Noga Meiri and Alfred H. Gitter and Torsten Sch{\"o}neberg and Joachim Mankertz and J{\"o}rg-Dieter Schulzke and Michael Fromm},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 24},
  pages={4969-76}
}
Tight junctions seal the paracellular pathway of epithelia but, in leaky tissues, also exhibit specific permeability. In order to characterize the contribution of claudin-2 to barrier and permeability properties of the tight junction in detail, we studied two strains of Madin-Darby canine kidney cells (MDCK-C7 and MDCK-C11) with different tight junctional permeabilities. Monolayers of C7 cells exhibited a high transepithelial resistance (>1 kOhms cm(2)), compared with C11 cells (<100 Ohms cm(2… CONTINUE READING
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