Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold.

@article{Itallie2009Claudin2dependentCI,
  title={Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold.},
  author={Christina M Van Itallie and Jennifer G Holmes and Arlene Bridges and James Melvin Anderson},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1165},
  pages={82-7}
}
Paracellular transport through the tight junction shows selectivity for both ionic charge and solute size. It is known that charged residues on the extracellular loops of claudins control charge selectivity. It is also known that inducible expression of claudin-2, but not claudin-4, will selectively increase the permeability for polyethylene glycol (PEG) molecules which are <0.4 A in radius, but it is not known whether permeability is controlled by the same regions of claudins which control… CONTINUE READING

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