Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance.

@article{Jovov2007Claudin18AD,
  title={Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance.},
  author={Biljana Jovov and Christina M Van Itallie and N J Shaheen and Johnny L. Carson and Todd M. Gambling and James Melvin Anderson and Roy Charles Orlando},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={293 6},
  pages={G1106-13}
}
Barrett's esophagus (BE) is a specialized columnar epithelium (SCE) that develops as replacement for damaged squamous epithelium (SqE) in subjects with reflux disease, and as such it is apparently more acid resistant than SqE. How SCE resists acid injury is poorly understood; one means may involve altered tight junctions (TJs) since the TJ in SqE is an early target of attack and damage by acid in reflux disease. To assess this possibility, quantitative RT-PCR for 21 claudins was performed on… CONTINUE READING

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