Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling

  title={Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling},
  author={Jong Min Baek and Yoon-Hee Cheon and Sung Chul Kwak and Hong Young Jun and Kwon-Ha Yoon and Myeung Su Lee and Ju-Young Kim},
  booktitle={Experimental & Molecular Medicine},
Claudins (Cldns) are well-established components of tight junctions (TJs) that play a pivotal role in the modulation of paracellular permeability. Several studies have explored the physiologic aspects of Cldn family members in bone metabolism. However, the effect of Cldn11, a major component of central nervous system myelin, on bone homeostasis has not been reported. In this study, we demonstrate that Cldn11 is a potential target for bone disease therapeutics as a dual modulator of osteogenesis… CONTINUE READING
2 Citations
46 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 46 references

CLDN11 as an epigenetic biomarker for malignancy

  • Gao, L. et al. Promoter CpG island hypermethylation in dys nevus, melanoma
  • J. Invest. Dermatol. 134, 2957–2966
  • 2014

Cldn-1 is a novel positive regulator of osteoblastogenesis

  • F. Z. Alshbool, Mohan, S. Differential expression of claudin family members osteoblast, osteoclast differentiation
  • PLoS ONE 9, e114357
  • 2014

Similar Papers

Loading similar papers…