Claudin 1 overexpression increases invasion and is associated with aggressive histological features in oral squamous cell carcinoma.

@article{Reis2008Claudin1O,
  title={Claudin 1 overexpression increases invasion and is associated with aggressive histological features in oral squamous cell carcinoma.},
  author={Patr{\'i}cia Pintor dos Reis and Rikki R. Bharadwaj and Jerry Machado and Christina Macmillan and Melania Pintilie and Mahadeo A Sukhai and Bayardo Perez-Ord{\'o}{\~n}ez and Patrick Gullane and Jonathan Irish and Suzanne Kamel-Reid},
  journal={Cancer},
  year={2008},
  volume={113 11},
  pages={3169-80}
}
BACKGROUND The authors have previously shown that overexpression of claudin 1 (CLDN1) is associated with advanced disease stage in oral squamous cell carcinomas (OSCCs). Their goal was to examine CLDN1 expression in a large series of primary OSCCs and to further investigate whether CLDN1 overexpression plays a role in invasion in OSCC. METHODS CLDN1 gene expression levels were determined by quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR) in 100 primary OSCCs… CONTINUE READING
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