Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.

@article{Chang2010Claudin1HT,
  title={Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.},
  author={Ti Ling Chang and Kosei Ito and Tun Kiat Ko and Qiang Liu and Manuel Salto-Tellez and Khay Guan Yeoh and Hiroshi Fukamachi and Yoshiaki Ito},
  journal={Gastroenterology},
  year={2010},
  volume={138 1},
  pages={255-65.e1-3}
}
BACKGROUND & AIMS The transcription factor RUNX3 is a gastric tumor suppressor. Tumorigenic Runx3(-/-) gastric epithelial cells attach weakly to each other, compared with nontumorigenic Runx3(+/+) cells. We aimed to identify RUNX3 target genes that promote cell-cell contact to improve our understanding of RUNX3's role in suppressing gastric carcinogenesis. METHODS We compared gene expression profiles of Runx3(+/+) and Runx3(-/-) cells and observed down-regulation of genes associated with cell… CONTINUE READING