Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas

@article{Paschoud2007Claudin1AC,
  title={Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas},
  author={Serge Paschoud and Massimo Bongiovanni and J Pache and Sandra Citi},
  journal={Modern Pathology},
  year={2007},
  volume={20},
  pages={947-954}
}
We investigated the expression of tight junction proteins in human lung squamous cell carcinomas and adenocarcinomas by immunohistochemistry and quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR). We found a statistically significant correlation between diagnosis and positivity of tumors with either claudin (CLDN)-1 or CLDN-5. Squamous cell carcinomas and basal cells of bronchial epithelium were positive for CLDN-1 and negative for CLDN-5, whereas adenocarcinomas… CONTINUE READING