Claudin-1, -3, -4 and -7 gene expression analyses in canine prostate carcinoma and mammary tissue derived cell lines.

@article{Hammer2016Claudin1,
  title={Claudin-1, -3, -4 and -7 gene expression analyses in canine prostate carcinoma and mammary tissue derived cell lines.},
  author={Susanne Conradine Hammer and Stefan Nagel and Johannes Junginger and Marion Hewicker-Trautwein and Siegfried Wagner and Alexander Heisterkamp and Anaclet Ngezahayo and Ingo Nolte and Hugo Murua Escobar},
  journal={Neoplasma},
  year={2016},
  volume={63 2},
  pages={
          231-8
        }
}
Claudins (CLDNs) are transmembrane proteins localised in the cell membrane of epithelial cells composing a structural and functional component of the tight junction protein complexes. In canine tumors deregulations of the CLDN expression patterns were described immunohistochemically. Targeting of claudin proteins has further been evaluated to establish novel therapeutic approaches by directed claudin binding. Precondition for the development of claudin targeting approaches in canine cells is… CONTINUE READING