Claude Bernard and the heart–brain connection: Further elaboration of a model of neurovisceral integration

@article{Thayer2009ClaudeBA,
  title={Claude Bernard and the heart–brain connection: Further elaboration of a model of neurovisceral integration},
  author={J. Thayer and R. Lane},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2009},
  volume={33},
  pages={81-88}
}
  • J. Thayer, R. Lane
  • Published 2009
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
The intimate connection between the brain and the heart was enunciated by Claude Bernard over 150 years ago. In our neurovisceral integration model we have tried to build on this pioneering work. In the present paper we further elaborate our model. Specifically we review recent neuroanatomical studies that implicate inhibitory GABAergic pathways from the prefrontal cortex to the amygdala and additional inhibitory pathways between the amygdala and the sympathetic and parasympathetic medullary… Expand
A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health
TLDR
A meta-analysis of recent neuroimaging studies on the relationship between heart rate variability and regional cerebral blood flow identified a number of regions, including the amygdala and ventromedial prefrontal cortex, in which significant associations across studies were found. Expand
The hierarchical basis of neurovisceral integration
TLDR
An updated/expanded version of the NVI model is presented that incorporates recent advances in functional neuroanatomy, and a class of computational models of brain function known as "predictive coding" models are illustrated to increase understanding of the relationship between vagal control and both cognitive performance and emotional/physical health. Expand
Stress and aging: A neurovisceral integration perspective.
TLDR
A framework based on the concept of neurovisceral integration is provided and it is proposed that stress regulation is emotion regulation and studies that have investigated emotion regulation may yield insights into successful stress regulation that helps protect people from age-related decline. Expand
Neural Correlates of Heart Rate Variability: Threat and Safety Perception
  • 2018
The connection between the heart and the brain was coined 150 years ago by Claude Bernard and has since then been an interesting topic of research. Scientists have for many years searched forExpand
Neurovisceral integration in the executive control network: A resting state analysis
TLDR
Right DLPFC-MFG seed pair provided strongest support for neurovisceral integration indexed by HF-HRV, low TA and shorter reaction time on the attention network task, suggesting hemispheric effect may underlie the inhibitory role of right PFC in the regulation of cardio-autonomic function, emotion, and executive attention. Expand
Brain-heart interaction in perseverative cognition.
TLDR
This is a review of studies conducted in different settings, populations, locations, and age groups that consistently replicated the association between autonomic, subjective, and behavioral measures of cognitive inflexibility during perseverative cognition, and suggests that HRV reduction from pre- to post-induction of perseveration cognition is associated with both structural and functional brain abnormalities reflecting impaired prefrontal inhibitory control over subcortical structures. Expand
Heart Rate Variability, Prefrontal Neural Function, and Cognitive Performance: The Neurovisceral Integration Perspective on Self-regulation, Adaptation, and Health
TLDR
An important relationship among cognitive performance, HRV, and prefrontal neural function that has important implications for both physical and mental health is suggested. Expand
Asymmetric sympathetic output: The dorsomedial hypothalamus as a potential link between emotional stress and cardiac arrhythmias
TLDR
Related findings in humans and animals are discussed, aiming to understand the neurogenic background for the origin of emotional stress-induced cardiac arrhythmias. Expand
Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights
TLDR
There are numerous evidences supporting the existence of a neurovisceral connection with multiorgan involvement that controls, among others, the cardiovascular function, which is asymmetrically organized. Expand
Structural Covariance of the Prefrontal-Amygdala Pathways Associated with Heart Rate Variability
TLDR
The results provide anatomical substrates for the neurovisceral integration model that resting HRV may index an integrative neural network which effectively organizes emotional, cognitive, physiological and behavioral responses in the service of goal-directed behavior and adaptability. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 118 REFERENCES
Ventral medial prefrontal cortex and cardiovagal control in conscious humans
TLDR
The hypothesis that the vMPFC is involved in modulating the vagal efferent outflow to the heart and the suppression of its activity elevates cardiovascular arousal in conscious humans is supported. Expand
Heart rate variability as an index of prefrontal neural function in military settings
In the present paper we describe a model of neurovisceral integration in which a set of neural structures involved in cognitive, affective, and autonomic regulation are related to heart rateExpand
Psychosomatics and psychopathology: looking up and down from the brain
TLDR
Supporting evidence from recent studies of the reflexive startle blink, attention and working memory, which shows that low HRV predicts hypervigilance and inefficient allocation of attentional and cognitive resources, is discussed. Expand
Central autonomic control of the heart, angina, and pathogenic mechanisms of post-myocardial infarction depression.
TLDR
Evidence is provided that cingulate cortex dysfunction may underlie occurrence of mood disorders and derangement of cardiac autonomic control, which would explain the increased risk of mortality associated with post-MI depression. Expand
Beyond Heart Rate Variability
TLDR
Vagal activity appears to play an inhibitory function in the regulation of allostatic systems associated with glucose regulation, hypothalamic‐pituitary‐adrenal (HPA) axis function, and inflammatory processes. Expand
A model of neurovisceral integration in emotion regulation and dysregulation.
TLDR
The outlines of a model that integrates autonomic, attentional, and affective systems into a functional and structural network that may help to guide us in the understanding of emotion regulation and dysregulation are presented. Expand
An autonomic flexibility–neurovisceral integration model of anxiety and cardiac vagal tone
  • B. Friedman
  • Medicine, Psychology
  • Biological Psychology
  • 2007
TLDR
A portrayal of anxiety as a restricted response range across biological and behavioral realms of functioning is drawn from the literature on anxiety and HRV. Expand
The functional neuroanatomy of emotion and affective style
TLDR
It is proposed that the PFC plays a crucial role in affective working memory and is most directly involved in the representation of elementary positive and negative emotional states while the dorsolateral PFC may be involved inThe representation of the goal states towards which these elementarypositive and negative states are directed. Expand
Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence.
TLDR
Converging neuroimaging and clinical findings suggest that ACC function mediates context-driven modulation of bodily arousal states during effortful cognitive and motor behaviour. Expand
Role of Orbitofrontal Cortex Connections in Emotion
  • N. Rempel-Clower
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 2007
TLDR
The complex connections between the orbit ofrontal cortex and the amygdala, as well as other areas involved in emotion, suggest important implications for the role of the orbitofrontal cortex in anxiety disorders, in which emotional expression is not appropriate to the situation. Expand
...
1
2
3
4
5
...