Clathrin-mediated endocytosis is essential in Trypanosoma brucei.

  title={Clathrin-mediated endocytosis is essential in Trypanosoma brucei.},
  author={Clare L Allen and David A. Goulding and Mark C. Field},
  journal={The EMBO journal},
  volume={22 19},
In Trypanosoma brucei, the plasma membrane is dominated by glycosylphosphatidylinositol (GPI)-anchored proteins. Endocytic activity correlates with expression levels of the clathrin heavy chain TbCLH, and additional evidence suggests that rapid endocytosis may play a role in evasion of the immune response. TbCLH is present on both endocytic vesicles and post-Golgi elements, suggesting a similar range of functions in trypanosomes to higher eukaryotes. We have assessed the role of TbCLH using RNA… CONTINUE READING
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