Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.

@article{Kirchhausen1987ClathrinLC,
  title={Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.},
  author={Tomas Kirchhausen and P. Scarmato and Stephen C Harrison and James Monroe and E. Pingchang Chow and Robert J. Mattaliano and Kavitha Ramachandran and John E. Smart and Andrew H. Ahn and J{\"u}rgen Brosius},
  journal={Science},
  year={1987},
  volume={236 4799},
  pages={320-4}
}
The clathrin light chains fall into two major classes, LCA and LCB. In an intact clathrin triskelion, one light chain, of either class, is bound to the proximal segment of a heavy chain leg. Analysis of rat brain and liver complementary DNA clones for LCA and LCB shows that the two light chain classes are closely related. There appear to be several members of each class having deletions of varying length aligned at the same position. A set of ten heptad elements, characteristic of alpha-helical… CONTINUE READING

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