Clathrin-binding proteins: got a motif? Join the network!

  title={Clathrin-binding proteins: got a motif? Join the network!},
  author={Esteban C Dell'angelica},
  journal={Trends in cell biology},
  volume={11 8},
Clathrin plays a key function in membrane and protein trafficking through the endocytic and late secretory pathways. Its role as a molecular scaffold that drives formation of transport vesicles requires binding to a number of proteins with distinct functional and structural properties. Recent studies have revealed that most of these proteins interact with clathrin through surprisingly simple, linear arrangements of acidic and hydrophobic amino acid residues. This article discusses the different… CONTINUE READING