Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis

@inproceedings{Bucher2018ClathrinadaptorRA,
  title={Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis},
  author={Delia Bucher and Felix Frey and Kem A. Sochacki and Susann Kummer and Jan-Philip Bergeest and William J. Godinez and Hans-Georg Kr{\"a}usslich and Karl Rohr and Justin W Taraska and Ulrich S. Schwarz and Steeve Boulant},
  booktitle={Nature Communications},
  year={2018}
}
Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it was recently suggested that clathrin first assembles to form flat structures that then bend while maintaining a constant surface area. Here, we combine correlative electron and light microscopy and mathematical growth laws to study the ultrastructural… CONTINUE READING
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Design principles for robust vesiculation in clathrin-mediated endocytosis.

Proceedings of the National Academy of Sciences of the United States of America • 2017

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