Clastogenic effects of acrylamide in mouse bone marrow cells.

  title={Clastogenic effects of acrylamide in mouse bone marrow cells.},
  author={I D Adler and Ingo Ingwersen and Uta Kliesch and A el Tarras},
  journal={Mutation research},
  volume={206 3},
Acrylamide, known to induce dominant-lethal mutations (Shelby et al., 1986; Smith et al., 1986) and heritable translocations (Shelby et al., 1987) in rodent germ cells, was hitherto a questionable clastogen in rodent bone marrow (Shiraishi, 1978). Therefore, it was tested for chromosomal aberrations in mouse bone marrow cells, spermatogonia and by the micronucleus test. The intraperitoneally injected doses ranged from 50 to 150 mg/kg. In the chromosomal bone marrow test and the micronucleus… CONTINUE READING


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