Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

  title={Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes},
  author={Zsolt Gelencs{\'e}r and Kumari Sonal Choudhary and Bruna Goncalves Coutinho and Sanjarbek Hudaiberdiev and Borisz Galb{\'a}ts and Vittorio Venturi and S{\'a}ndor Pongor},
Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16… CONTINUE READING
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