Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study

  title={Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study},
  author={William A. Newton and Edmund A. Gehan and Bruce L. Webber and Henry Basil Marsden and A. J. M. van Unnik and Ala B. Hamoudi and Maria Tsokos and Hiroyuki Shimada and Dieter Harms and Dietmar Schmidt and Vito Ninfo and Andrea O. Cavazzana and F. Gonzalez-crussi and David M. Parham and Herbert M. Reiman and Lina Asmar and Mohan S. Beltangady and Nancy Sachs and Timothy J. Triche and Harold M. Maurer},
Background. There is a need to develop a single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors of children, adolescents, and young adults which would be a current guide for their diagnosis, allow valid comparison of outcomes between protocols carried out anywhere in the world, and should enhance recognition of prognostic subsets. 
Rhabdomyosarcoma. Biology and treatment.
Pretreatment TNM staging of childhood rhabdomyosarcoma
Potential staging elements were retrospectively evaluated in a subset of 505 patients who participated in IRS‐II, an IRSG clinical trial, for assessing the posttreatment outcomes of patients with this disease.
Rhabdomyosarcoma of the Upper Lip in an Adult Patient
A rare case of primary RMS, embryonal type, occurring on the upper lip in a 27-year-old female is reported.
Rhabdomyosarcoma in adults
This finding casts doubt on whether RMS is the same disease in adults as it is in children, as published series have reported definitively worse results.
Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975‐2005
The authors of this report evaluated incidence and survival trends by RMS demographic subgroups to inform future etiologic hypotheses.
Prevalence and clinical impact of anaplasia in childhood rhabdomyosarcoma
A recent review of cases from the Soft Tissue Sarcoma Committee of the Children's Oncology Group suggests that anaplasia might be more common than previously reported and may impact clinical outcome.
A case of bladder rhabdomyosarcoma in an adult
A case of embryonal rhabdomyosarcoma arising in the bladder of a 29-year-old man who presented with dysuria and microscopic hematuria is reported.
Primary pulmonary rhabdomyosarcoma in an adult: a case report and review of the literature
  • G. Ji, H. Mao
  • Medicine
    Journal of Zhejiang University SCIENCE B
  • 2013
Primary pulmonary rhabdomyosarcoma is one of the most common soft-tissue malignancies in children, but is rare in persons aged >45 years, and is frequently misdiagnosed as small cell lung cancer.
Embryonal rhabdomyosarcoma: A rare oral tumor
A case of embryonal rhabdomyosarcoma in the left posterior buccal mucosa, with extension in the adjacent alveolus, soft palate, oropharynx and nasopharynx of a 17-year-old female is described.
Is alveolar histotype a prognostic factor in paratesticular rhabdomyosarcoma? The experience of Italian and German Soft Tissue Sarcoma Cooperative Group
To ascertain whether alveolar histology retains its adverse prognostic role in the subset of paratesticular rhabdomyosarcoma (RMS) patients, generally characterized by a very good outcome.


Histopathological classification of childhood rhabdomyosarcoma: a report from the International Society of Pediatric Oncology pathology panel.
The histological diagnosis of all referred tumours is given, and a classification of rhabdomyosarcomas developed during the course of the study is described, thought to be helpful in diagnosis and also in assessment of the likelihood of recurrence and/or metastasis of childhood rhabdomsarcoma.
Agreement among and within groups of pathologists in the classification of rhabdomyosarcoma and related childhood sarcomas. Report of an international study of four pathology classifications
The agreement demonstrated among and within groups of pathologists involved in the categorization of childhood rhabdomyosarcoma according to four pathology classifications was measured.
Rhabdomyosarcoma in children: Ultrastructural study of 31 cases
All childhood forms of rhabdomyosarcoma are essentially embryonal tumors, with many not being sufficiently differentiated at the cellular level to allow positive ultrastructural diagnosis.
Rhabdomyosarcoma. A new classification scheme related to prognosis.
The data indicate that the NCI scheme can serve as a highly predictive, independent prognostic factor in RMS and that the alveolar category should be expanded to include the solid round-cell RMS, even in the absence of a classic alveolarship.
Immunohistochemical analysis of soft tissue sarcomas. Comparisons with electron microscopy.
This overview presents a summary of results of these 2 adjuvant modalities of pathologic analysis, as applied to the spectrum of malignant soft tissue neoplasms.
Alveolar rhabdomyosarcoma with the t(2;13): cytogenetic findings and clinicopathologic correlations.
The clinical and pathologic features associated with a specific translocation, t(2;13), in alveolar rhabdomyosarcoma are described, with a median survival time of 6 months from diagnosis and one patient survives free of disease.
Spindle Cell Variants of Embryonal Rhabdomyosarcoma in the Paratesticular Region: A Report of the Intergroup Rhabdomyosarcoma Study
It is concluded that spindle-cell RMS is a subtype of embryonal RMS with a very favorable prognosis and the site factor of the paratesticular localization may allow earlier diagnosis of the spindle-cell lesions compared with other sites.
Spindle Cell Rhabdomyosarcoma: A Prognostically Favorable Variant of Rhabdomyosarcoma
Analysis of the results determined that spindle cell rhabdomyosarcoma constitutes a rare variant of the embryonal form, showing a high degree of skeletal muscle differentiation and a low malignant potential; it should therefore be distinguished from classical forms of embryonal rhabidonia.
Extremity lesions in the intergroup rhabdomyosarcoma study (IRS‐I): A preliminary report
Increased rates of relapse were seen in patients with extremity tumors, as opposed to tumors in other sites, irrespective of the specific IRS chemotherapy‐radiotherapy regimen employed.
Prognostic significance of staging factors of the UICC staging system in childhood rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study (IRS-II).
A retrospective assessment of the relationship of these pretreatment observations to survival experience indicates definite prognostic significance for all of the individual factors used on the International Union Against Cancer (UICC) pretreatment staging system except clinical status of regional nodes.