Classification of male factor infertility relevant to in-vitro fertilization insemination strategies using mannose ligands, acrosome status and anti-cytoskeletal antibodies.

@article{Benoff1996ClassificationOM,
  title={Classification of male factor infertility relevant to in-vitro fertilization insemination strategies using mannose ligands, acrosome status and anti-cytoskeletal antibodies.},
  author={Susan H Benoff and Michele Barcia and Ian R Hurley and George W. Cooper and Francine S. Mandel and Susan Heyner and William T. Garside and Bruce R. Gilbert and Avner Hershlag},
  journal={Human reproduction},
  year={1996},
  volume={11 9},
  pages={
          1905-18
        }
}
Polyvalent mannose ligands in the presence of free mannose act as zona pellucida agonists which rapidly induce acrosome exocytosis in competent motile human sperm from fertile donors following in-vitro capacitation. Quantification of the binding patterns of fluorescein isothiocyanate-labelled mannosylated albumins and of specific antisera which recognize mannose receptors and other related integral sperm membrane proteins as well as the incidence of induced acrosome exocytosis after… CONTINUE READING
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