Classification of lymphoid neoplasms: the microscope as a tool for disease discovery.

@article{Jaffe2008ClassificationOL,
  title={Classification of lymphoid neoplasms: the microscope as a tool for disease discovery.},
  author={Elaine S. Jaffe and Nancy Lee Harris and Harald Von Stein and Peter Gershon Isaacson},
  journal={Blood},
  year={2008},
  volume={112 12},
  pages={4384-99}
}
In the past 50 years, we have witnessed explosive growth in the understanding of normal and neoplastic lymphoid cells. B-cell, T-cell, and natural killer (NK)-cell neoplasms in many respects recapitulate normal stages of lymphoid cell differentiation and function, so that they can be to some extent classified according to the corresponding normal stage. Likewise, the molecular mechanisms involved the pathogenesis of lymphomas and lymphoid leukemias are often based on the physiology of the… CONTINUE READING

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