Classification of low quality cells from single-cell RNA-seq data

  title={Classification of low quality cells from single-cell RNA-seq data},
  author={Tomislav Ilicic and Jong Kyoung Kim and Aleksandra A Kolodziejczyk and Frederik Otzen Bagger and Davis James McCarthy and John C. Marioni and Sarah A. Teichmann},
  booktitle={Genome Biology},
Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical research. One of the key challenges is to ensure that only single, live cells are included in downstream analysis, as the inclusion of compromised cells inevitably affects data interpretation. Here, we present a generic approach for processing scRNA-seq data and detecting low quality cells, using a curated set of over 20 biological and technical features. Our approach improves classification accuracy by over 30… CONTINUE READING
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