Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.

@article{Simmonds1993ClassificationOH,
  title={Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.},
  author={P. Simmonds and E. Holmes and T. Cha and S. Chan and F. Mcomish and B. Irvine and E. Beall and P. Yap and J. Kolberg and M. Urdea},
  journal={The Journal of general virology},
  year={1993},
  volume={74 ( Pt 11)},
  pages={
          2391-9
        }
}
Hepatitis C virus (HCV) showed substantial nucleotide sequence diversity distributed throughout the viral genome, with many variants showing only 68 to 79% overall sequence similarity to one another. Phylogenetic analysis of nucleotide sequences derived from part of the gene encoding a non-structural protein (NS-5) has provided evidence for six major genotypes of HCV amongst a worldwide collection of 76 samples from HCV-infected blood donors and patients with chronic hepatitis. Many of these… Expand
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