Classification of dissolution profiles in terms of fractional dissolution rate and a novel measure of heterogeneity.

Abstract

Dissolution profiles are classified in accordance with the shape of fractional dissolution rate function. This function is constant in time for the classical first-order model and, in this case, the dissolution is described by a monoexponential function. Therefore, any deviation of the fractional dissolution rate from the constant level suggests the presence of different (nonlinear/nonhomogenous) mechanisms in the dissolution process. The shapes of the fractional dissolution rate depend on the type of the model of dissolution; thus, classification with respect to this function is proposed as a tool for model selection. The Kullback-Leibler information distance is proposed for measuring similarity between two different drug dissolution profiles. The method is applied mainly to compare the first-order model, which characterizes a homogenous dosage form, with other common descriptors of dissolution and with experimental data.

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@article{Lnsk2003ClassificationOD, title={Classification of dissolution profiles in terms of fractional dissolution rate and a novel measure of heterogeneity.}, author={Petr L{\'a}nsk{\'y} and Michael Wei\ss}, journal={Journal of pharmaceutical sciences}, year={2003}, volume={92 8}, pages={1632-47} }